Organizing Committee

Han-Jia Lin, National Taiwan Ocean University, Taiwan
Kazuei Igarashi, Chiba University, Japan
Enzo Agostinelli, SAPIENZA University of Rome, Italy

Scientific Advisory Board

E. Agostinelli (Italy)
G. Canettieri (Italy)
S.K. Gilmour (USA)
K. Igarashi (Japan)
C. Kahana (Israel)
A. Khomutov (Russia)
H. J. Lin (Taiwan)
A. Mattoo (USA
S. Matsufuji (Japan)
T. Oka (Japan)
M.H. Park (USA)
O. Phanstiel (USA)
A. Toninello (Italy)
L. Vardy (Singapore)
J. Y. Wang (USA)
K.T. Wilson (USA)
P.M. Woster (USA)

Organizing Secretariat

Han-Jia Lin PhD
Professor
Department of Bioscience and Biotechnology
National Taiwan Ocean University
No.2 Beining Rd., Keelung 202-24, Taiwan
Tel:+886-2- 24622192 ext 5507
Fax:+886-2- 24622320
E-mail: hanjia@ntou.edu.tw

Enzo Agostinelli PhD
Professor
Department of Biochemical Sciences “A. Rossi Fanelli”
SAPIENZA University of Rome
Piazzale A. Moro, 5 –00185 Rome- Italy
Tel.: +39 (0)6 49910838
Fax: +39 (0)6 4440062
e-mail: enzo.agostinelli@uniroma1.it

Tentative program

1) POLYAMINES IN CELL GROWTH AND DIFFERENTIATION
2) POLYAMINES METABOLISM, TRANSPORT AND SIGNAL TRANSDUCTION
3) POLYAMINES AND PHYSIOLOGY
4) POLYAMINES IN NUTRITION AND LONGEVITY
5) POLYAMINES IN HUMAN HEALTH: IN CANCER AND OTHER DISEASES. THERAPEUTIC APPLICATIONS
6) POLYAMINES AND THEIR ANALOGS: CHEMISTRY AND MOLECULAR PHARMACOLOGY
7) eIF5A AND TRANSLATION
8) POLYAMINES IN PLANTS AND IN BIOTECHNOLOGICAL APPLICATIONS
9) POLYAMINES AND TRANSGLUTAMINASES
10) POLYAMINES METABOLISM IN PARASITES AND OTHER MICROORGANISMS

Oral presentations will be selected from the submitted abstracts. Time will be provided for poster
presentations and informal discussions

10:30am 12:30pm	Registration at the Howard Civil Service International House
12:30pm 2:00pm	Lunch
4:30pm 5:00pm	Opening Ceremony

5:00pm 6:30pm	Opening Lectures	Session leaders: E. Agostinelli (SAPIENZA University of Rome, Italy)	H. Lin (National Taiwan Ocean University, Taipei, Taiwan)
5:00pm 5:45pm	[PL 01]	R. A. Casero (Johns Hopkins University, USA)	Targeting polyamine metabolism for chemoprevention
5:45pm 6:30pm	[PL 02]	K. Igarashi (Chiba University, Japan)	Acrolein toxicity at advanced age
5:00pm 6:45pm	Registration at the Howard Civil Service International House Taipei
6:45pm 09:00pm	Welcome dinner at the Howard Civil Service International House Taipei

9:00am 10:15am	Session 1: POLYAMINES IN CELL GROWTH AND DIFFERENTIATION	Session leader: T. Oka (Wakunaga Pharmaceutical Co.Ltd, Japan)
9:00am 9:25am	[L 03]	M.H. Park (National Institutes of Health, USA)	A potential interplay between polyamine and Mg pathways in the regulation of eukaryotic cell proliferation
9:25am 9:50am	[L 04]	L.A. Vardy (Instit. of Medical Biology, Singapore)	Polyamine mediated regulation of the epidermis: Barrier formation and pigmentation
9:50am 10:15am	[L 05]	K. Kashiwagi (Chiba Institute of Science, Japan)	Polyamine stimulation of the synthesis of histone acetyltransferases, Gcn5 and Hat1
10:15am 10:45am	Coffee Break

10:45am 12:00pm	Session 2: eIF5A AND TRANSLATION	Session leader: R.G. Mirmira (Indiana University, Indianapolis, USA)
10:45am 11:10am	[L 06]	C. Kahana (Weizmann Institute of Science, Israel)	Investigating the mechanism leading to proliferative arrest of polyamine depleted cells
11:10am 11:35am	[L 07]	T.L. Mastracci (Indiana Biosciences Res Institute,USA)	Hypusine biosynthesis is required for proper development and growth in mouse and human
11:35am 12:00pm	[L 08]	A. Kaiser (University Duisburg-Essen, Germany)	eIF5A prevents cardiac symptoms in experimental cerebral malaria through apoptosis

12:00pm 12:25pm	Session 3: POLYAMINES IN NUTRITION AND LONGEVITY	Session leader: A. Toninello (University of Padova, Italy)
11:35am 12:00pm	[L 09]	K. Soda (Saitama Medical Center, Japan)	Increased polyamine intake elevates blood spermine levels and suppresses expression of lymphocyte function-associated antigen 1 (LFA-1) on human immune cells. – an interventional study –
12:30pm	Photograph
12:45pm	Lunch

5^th International Conference on Polyamines: Biochemical, Physiological and Clinical Perspectives

Organizing Committee

Scientific Advisory Board

Organizing Secretariat

Tentative program

Scientific program:

In progress

Download program in pdf

4:30pm 6:35pm	Session 4 : POLYAMINES METABOLISM, TRANSPORT AND SIGNAL TRANSDUCTION	Session leader: C. Kahana (Weizmann Institute of Science, Israel)
4:30pm 4:55pm	[L 10]	R.G. Mirmira (Indiana University, Indianapolis, USA)	Deoxyhypusine synthase is required for the adaptive proliferative response of the islet β cell
4:55pm 5:20pm	[L 11]	A. Tajima (The Jikei University, Japan)	Antizyme and ATP citrate lyase suppresses the cell death of ornithine decarboxylase-overproducing cell line
5:20pm 5:45pm	[L 12]	N.L. Chan (National Taiwan University)	Structural basis of antizyme-mediated regulation of polyamine homeostasis
5:45pm 6:10pm	[L 13]	S. Fujiwara (Kwansei-Gakuin University, Japan)	Physiological roles of branched-chain polyamine in hyperthermophile: effect of BCPA on gene expressions in hyperthermophilic archaea
		Session leaders: E. Agostinelli (SAPIENZA University of Rome, Italy)
6:10pm 6:35pm	[L 14]	D. Spandidos (Emeritus University of Crete, Greece) Editor Spandidos Publications Ltd	Publishing in Biomedical Sciences
6:45pm 8:30pm	Dinner
8:45pm 11:00pm	Taipei by night

2:30pm 2:40pm	[P 01]	Y. Terui (Chiba Institute of Science, Chiba, Japan)	Role of polyamines on cell growth under high temperature environment
2:40pm 2:50pm	[P 02]	A. Oguro (The Jikei University School Medicine Japan)	Polyamines promiscuously induce +1 ribosomal frameshifting in a human cell-free translation system
2:50pm 3:00pm	[P 03]	C.T. Lee (National Taiwan Ocean University, Taiwan)	Production of longer uncommon polyamines in Escherichia coli with polyamine synthase gene from diatom
3:00pm 3:10pm	[P 04]	K. Saya (Kwansei-Gakuin University, Japan)	The method of making Agmatine rich rice syrup
3:10pm 3:20pm	[P 05]	E. Neborak (Peoples’ Friendship University of Russia)	The lymphocytes of brain glioma patients excrete polyamine oxidation enzymes after phytohemagglutinin stimulation
3:20pm 3:30pm	[P 06]	Y.H. Cheng (National Taiwan Ocean University, Taiwan)	Identification of functional motifs of silica affinity protein, which interacting with the long-chain polyamine for biomineralization in marine diatom Phaeodactylum tricornutum

9:00am 12:45pm	Session 5 : POLYAMINES IN BIOTECHNOLOGICAL APPLICATIONS	Session leader: O. Phanstiel IV (University of Central Florida, USA)
9:00am 9:25am	[L 15]	F. Vianello (University of Padova, Italy)	Biotechnological applications of nanostructured hybrids of polyamine based quantum dots and iron oxide nanoparticles
9:25am 9:50am	[L 16]	H.J. Lin (National Taiwan Ocean University, Taiwan)	High efficient and safe bactericides derived from polyamines and their applications in aquaculture
9:50am 10:15am	[L 17]	X.H. Makhoba (University of Zululand, South Africa)	Polyamines-modified nanoparticles and molecular chaperones assembled nanoparticles synthesis in enhancing healing of diabetic wounds
10:15am 10:40am	[L 18]	P.M. Woster (Medical University of South Carolina, USA)	How we did it: the discovery of a new chemical scaffold for SMOX inhibition
10:40am 11:10am	Coffee Break

11:10am 12:25pm	Session 6 : POLYAMINES IN PLANTS	Session leader: K. Igarashi (Chiba University, Japan)
11:10am 11:35am	[L 19]	A. Mattoo (Beltsville Agricultural Res Center, USA)	Polyamines: Signaling Molecules in Plant Health and Death
11:35am 12:00pm	[L 20]	J. Zepeda-Jazo(University La Ciénega Michoacán, Mexico)	Technical approach for electrophysiological studies of polyamines effects on ion transport across plant membranes
12:00pm 12:25pm	[L 21]	S.H. Su (University of Wisconsin-Madison, USA)	Polyamines alter primary root growth by modulating biotin synthesis
12:30pm 1:00pm	Lunch
1:45pm 6:45pm	Sightseeing
7:00pm 9:00pm	Dinner

9:00am 12:50pm	Session 7: POLYAMINES IN HUMAN HEALTH: IN CANCER AND OTHER DISEASES. THERAPEUTIC APPLICATIONS (First part)	Session leader: R. A. Casero (Johns Hopkins University, USA)
9:00am 9:25am	[L 22]	K.T. Wilson (Vanderbilt University Medical Center, USA)	New insights into immunoregulatory effects of polyamines in gastrointestinal inflammation and carcinogenesis
9:25am 9:50am	[L 23]	S.K. Gilmour (Lankenau Institute for Medical Res, USA)	Anti-Tumor and immunomodulatory effects of novel arylpolyamine Drugs
9:50am 10:15am	[L 24]	T. Uemura (Amine Pharma Research Institute, Japan)	N-acetylcysteine derivatives decrease infarction volume by stabilizing glutathione S-transferases
10:15am 10:40am	[L 25]	E. Agostinelli (SAPIENZA University of Rome, Italy)	Enzymatic spermine metabolites cause apoptosis in tumor cells detected by flow cytometry, real time RT-PCR and proteomic analyses
10:40am 11:10am	Coffee Break
	Session leader: P. Mariottini (University “ROMA TRE”, Italy)
11:10am 11:35am	[L 26]	S. Merali (Temple School of Pharmacy Philadelphia, USA)	Scavenging of oxidative stress products by polyamine analogs as basis for diabetes treatment
11:35am 12:00pm	[L 27]	U. Bachrach (Hebrew University, Israel)	Green Tea and Polyamines – Past, Present and Future
12:00pm 12:25pm	[L 28]	A.Toninello (University of Padova, Italy)	Induction of mitochondrial permeability transition by spermine and bovine serum amine oxidase in hepatoma cell mitochondria. Potential mechanism for intrinsic apoptosis induction
12:25pm 12:50pm	[L 29]	J.C. Sierra (Vanderbilt University Medical Center, USA)	Spermine oxidase deletion confers protection from Helicobacter pylori-induced gastric inflammation and DNA damage
1:00pm 2:30pm	Lunch
3:00pm 4:00pm	Oral poster presentation	Session leaders: R. Jaladanky (University of Maryland, Baltimore, USA) T. Ueshima (Wakunaga Pharmaceutical Co. Ltd, Japan)
4:00pm 5:00pm	Poster session and Coffee break

5:00pm 6:15pm	Session 8: POLYAMINES AND PHYSIOLOGY	Session leader: E. Pirinen (University of Helsinki, Finland)
5:00pm 5:25pm	[L 30]	J.Y. Wang (University of Maryland, Baltimore, USA)	Regulation of intestinal epithelium homeostasis by polyamines through RNA-binding protein HuR and noncoding RNAs
5:25pm 5:50pm	[L 31]	M. Cervelli (University of Roma Tre, Italy)	The relationship between serotonergic system and polyamines system in aberrant emotional behaviour
5:50pm 6:15pm	[L 32]	T. Fukui (Saitama Medical Center, Japan)	Biological background by which polyamine regulates DNA methylation
6:30pm 8:15pm	Dinner
8:30pm 11:00pm	Taipei by night

3:00pm 3:10pm	[P 07]	M.L. Di Paolo (University of Padova, Padova, Italy)	Novel targets for “old” polyamine analogues: monoamine oxidases and benextramine derivatives
3:10pm 3:20pm	[P 08]	A. Sakamoto (Chiba Institute of Science, Chiba, Japan)	Development of an ELISA for a urinary metabolite of acrolein-glutathione conjugate
3:20pm 3:30pm	[P 09]	S. Krysenko (University of Tübingen, Germany)	Characterization of the gamma-glutamylpolyamine synthetase GlnA3 in Mycobacterium tuberculosis as a potential drug target
3:30pm 3:40pm	[P 10]	W. Fukuda (Kwansei-Gakuin University, Japan)	Effect of branched-chain polyamine on gene expression in the hyperthermophilic archaeon Thermococcus kodakarensis
3:40pm 3:50pm	[P 11]	Y. Yamori (Kwansei-Gakuin University, Japan)	Effect of branched-chain polyamine on RNA polymerase stabilization in the hyperthermophilic archaeon Thermococcus kodakarensis
3:50pm 4:00pm	[P 12]	H.Y. Lin (National Taiwan Ocean University, Taiwan)	Development of molecular toolbox for studying diatom polyamine synthases in Phaeodactylum tricornutum

9:00am 11:50am	Session 9: POLYAMINES IN HUMAN HEALTH: IN CANCER AND OTHER DISEASES. THERAPEUTIC APPLICATIONS (Second part)	Session leader: L.A. Vardy (Institute of Medical Biology, Singapore)
9:00am 9:25am	[L 33]	O. Phanstiel IV (University of Central Florida, USA)	Polyamine Depletion in Pancreatic Cancers via Amino Acid Deprivation
9:25am 9:50am	[L 34]	P.K. Epling-Burnette (Moffitt Cancer Center, Florida, USA)	Regulation and Roles of Polyamines in CD8+ T cell Immunity
9:50am 10:15am	[L 35]	P. Chi (National Taiwan University, Taipei, Taiwan)	Polyamines promote homology-directed DNA repair
10:15am 10:45am	Coffee Break
10:45am 11:10am	[L 36]	D.L.T. Koomoa (University of Hawaii at Hilo, Hawaii)	Polyamines promotes Neuroblastoma drug resistance through a process that involves novel calcium signaling pathways
11:10am 11:35am	[L 37]	A.P. Gobert (Vanderbilt University Medical Center, USA)	Cystathionine gamma-lyase regulates innate immunity through effects on polyamine balance in macrophages during Helicobacter pylori infection

11:35am 12:30pm	Meeting International Polyamines Foundation - ONLUS	E. Agostinelli, President	All the participants to the Conference are invited to attend
12:45pm 2:15pm	Lunch
2:45pm 3:45pm	Poster session and Coffee break

3:45pm 6:15pm	Session 10: POLYAMINES METABOLISM IN PARASITES AND OTHER MICROORGANISMS	Session leader: A. Kaiser (University Duisburg-Essen, Germany)
3:45pm 4:10pm	[L 38]	T. Oshima (Kyowa-Kako Co., Japan)	Why an extreme thermophile, Thermus thermophilus, can produce many different polyamines with a limited number of genes involved in polyamine biosynthesis?
4:10pm 4:35pm	[L 39]	A. Ilari (National Research Council of Italy, Italy)	Enzymes of the trypanothione-based redox metabolism and anti-kinetoplastid drug discovery
4:35pm 5:00pm	[L 40]	S.C. Roberts (Pacific University, USA)	Polyamines: paramount for parasite proliferation and persistence
5:00pm 5:25pm	[L 41]	B. Brider Verlinden (University of Pretoria, South Africa)	Multi-target Antimalarial Polyamine Analogues: Resisting Resistance
5:25pm 5:50pm	[L 42]	A. Zhgun (Center of Biotechnology RAS Moscow, Russia)	The relationship between polyamines and overproduction of secondary metabolites in filamentous fungi
5:50pm 6:15pm	Concluding Remarks	U. Bachrach (Hebrew University, Israel) E. Agostinelli (SAPIENZA University of Rome, Italy) H.J. Lin (National Taiwan Ocean University, Taiwan) K. Igarashi (Chiba University, Japan)
7:00pm	Gala Dinner

9:00am 11:30am	2018 Annual Meeting of Taiwanese Society for Polyamine Research	Special topic: Biosafety and applications of Herbmedotcin, a polyamine based carbon dot	Participants of the International Polyamines Conference are welcome to join the meeting
12:00pm	Lunch
1:30pm	Departure to Taiwan Airport

5th International Conference on Polyamines: Biochemical, Physiological and Clinical Perspectives

Organizing Committee

Scientific Advisory Board

Organizing Secretariat

Tentative program

Scientific program:

In progress

Download program in pdf

5^th International Conference on Polyamines: Biochemical, Physiological and Clinical Perspectives